In organizations:
- Taxi and Limousine Commission, the New York City government agency that regulates taxicabs and for-hire vehicles
- The Land Conservancy, a not-for-profit, charitable land trust based in British Columbia, Canada
- The Learning Company, an American educational software company
- The Leasing Center, an Australian Leasing company
- True and Living Church of Jesus Christ of Saints of the Last Days, an offshoot of The Church of Jesus Christ of Latter-day Saints

In locations:
- TLC, the IATA airport code for Lic. Adolfo López Mateos International Airport located at Toluca, State of Mexico, Mexico
- 'Technology and Learning Center', (renamed to Robbinsdale Middle School), a school in the Robbinsdale School District
- The Learning Center for Deaf Children, a school for Deaf and hard of hearing located in Framingham, Massachusetts