Lee also hosted the TV series Sex with Sophie Lee in 1991 and has appeared in several films, including the Australian comedies Muriel's Wedding, The Castle and He Died with a Felafel in His Hand.

Apart from acting, Lee was a member of the Australian pop/dance group Freaked Out Flower Children, who released the hit album Love In (1991) and the #32 single "Spill the Wine".

She has now branched into writing, releasing a book titled Alice in La La Land through Random House publishing.