Webb developed computer skills in her free time at Berkeley, and after graduating from college, worked for a dot-com company as a website administrator. After the company went under during the dot-com bubble burst of 2000, her friend Catherine Schwartz hired her at TechTV in 2001 and Morgan became employed as the associate producer and web researcher for The Screen Savers. Thanks to her self-taught knowledge of computers and technology, in addition to a camera-friendly appearance, she was quickly promoted to an on-screen member of the program where she presented daily in-depth segments dealing with Microsoft Windows and Linux operating systems, and on select occasions hosted The Screen Savers herself. Throughout 2002 and 2003, she regularly co-hosted Call For Help with Chris Pirillo. In April 2003, Webb left The Screen Savers to co-host X-Play with Adam Sessler.
Webb is one of only six TechTV personalities, including Adam Sessler, Sarah Lane, Chi-Lan Lieu, Kevin Rose, and Brendan Moran, to survive the massive layoffs resulting from the May 2004 merger of G4 and TechTV. However, since G4's change of format, only Adam Sessler and Morgan Webb remain on the network.
In August 2005, Webb became a contributing game columnist for FHM, alongside her regular hosting duties on X-Play. Her monthly column was titled "Tips From The Gaming Goddess". Readers were encouraged to email Morgan their video game-related inquiries; she would then answer one question each month. In February 2007, Webb wrote her final column for the magazine, as FHM discontinued its US publication later that March.
Webb graduated from Walter Reed Middle School in 1993 and graduated from North Hollywood High School in 1996 from the Highly Gifted Magnet. After graduating high school, she left home to attend UC Berkeley, where she earned a bachelor's degree in 2000 in rhetoric and a minor in Italian.
Throughout 2004, Webb was featured in numerous issues of print publications FHM and Maxim:
- She was spotlighted in the July 2004 issue of Maxim.
- She had a five-page feature article in the November 2004 issue of FHM
- She was voted "Hottest Woman of the Year" in RTD's 2006 Top 10 countdown
- She was featured in the Fall 2006 Edition of Colleges.com U Magazine
- She was voted #73 in FHM's 2005 list of The 100 Sexiest Women In The World
- She was voted #62 in FHM's 2006 list of The 100 Sexiest Women In The World
- She was voted #51 in FHM's 2007 list of The 100 Sexiest Women In The World
Webb has appeared in the music video Strange New Element from the band Low Water. She makes her appearance near the end of the video alongside other fellow TechTV personalities, including Catherine Schwartz, Sarah Lane, Laura Swisher, Chi-Lan Lieu, and Sumi Das. In addition to appearing in Low Water's music video, Morgan is featured in the artwork of the band's album, Hard Words In A Speakeasy.