Khan was born as Jemima Marcelle Goldsmith, the daughter of billionaire Sir James Goldsmith and Lady Annabel Vane-Tempest-Stewart. When Jemima was born, both her parents were married to other people. . After the birth of her brother Zac in 1975, her mother and father proceeded to divorce their respective spouses. Her parents were married in 1978. Throughout the marriage, Jemima's father maintained simultaneous relationships with his second wife, Jemima's mother and his mistresses, among them Jemima's own first cousin Lady Cosima Somerset, daughter of Annabel's brother, the 9th Marquess of Londonderry.
Her parents had another child together Ben in 1980. In 1981, her father moved to New York with Laure Boulay, Comtesse de la Meurthe, his mistress and a member of the Bourbon family, leaving Jemima and her siblings at home in Surrey, England with their mother. However her parents remained married until her father's death.,
Jemima Goldsmith excelled academically at Francis Holland School Clarence Gate and has also proved to be a talented horsewoman. It seemed likely that she would become a professional equestrienne but she chose to continue her studies. In 1993, she enrolled for an English degree at Bristol University.
Imran set out to pursue a career in politics as the leader of the Movement for Justice Party in Pakistan Pakistan Tehreek-e-Insaf. Jemima working tirelessly with her husband, became fluent in Urdu and had their first son Suleiman in 1997 while campaigning to improve the literacy level in Pakistan. Their second son, Qasim, was born in 1999. Both her sons are good at cricket, Qasim especially - his right arm legspin already earning him wickets that would make his father proud.
After moving to Pakistan with her husband she embarked on a series of business ventures, including her own brand of tomato ketchup and the "Jemima Khan" fashion label which closed in 2001. All profits from her entrepreneurial ventures went to the Shaukat Khanum Memorial Cancer hospital, named for her husband's mother.
In Lahore, Khan lived in very simple, traditional conditions in her father-in-law's house with her extended family. She explained,"I think the fact that I was very young made it easier to adjust and fit in. Certainly, I couldn’t make a change like that now."
The fact that she had distant Jewish ancestry would prove to be of great consequence for her husband's political career. She was vilified in many Pakistani newspapers. Religious groups demanded that her citizenship be revoked. . She and her husband were accused and detained on false charges of smuggling antiques out of Pakistan. Of her experiences she said: "I had to over-conform, and I had to make a double effort to be seen to do the right thing, because I was a foreigner with a Jewish background. I was his Achilles heel, politically, and he has a reputation for being honest and straightforward and uncorrupt. So a way of attacking him was to attack me."
Their marriage suffered yet another blow when it was revealed that another British heiress, Sita White, had a child by Imran Khan prior to his marriage to Jemima. Her husband denied paternity of White's child. It is not clear if any DNA testing was ever carried out.