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Thread: Online gamers crack AIDS enzyme puzzle

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    fgg
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    Default Online gamers crack AIDS enzyme puzzle

    Online gamers crack AIDS enzyme puzzle

    Online gamers have achieved a feat beyond the realm of Second Life or Dungeons and Dragons: they have deciphered the structure of an enzyme of an AIDS-like virus that had thwarted scientists for a decade.

    The exploit is published on Sunday in the journal Nature Structural & Molecular Biology, where -- exceptionally in scientific publishing -- both gamers and researchers are honoured as co-authors.

    Their target was a monomeric protease enzyme, a cutting agent in the complex molecular tailoring of retroviruses, a family that includes HIV.

    Figuring out the structure of proteins is vital for understanding the causes of many diseases and developing drugs to block them.

    But a microscope gives only a flat image of what to the outsider looks like a plate of one-dimensional scrunched-up spaghetti. Pharmacologists, though, need a 3-D picture that "unfolds" the molecule and rotates it in order to reveal potential targets for drugs.

    This is where Foldit comes in.

    Developed in 2008 by the University of Washington, it is a fun-for-purpose video game in which gamers, divided into competing groups, compete to unfold chains of amino acids -- the building blocks of proteins -- using a set of online tools.

    To the astonishment of the scientists, the gamers produced an accurate model of the enzyme in just three weeks.

    Cracking the enzyme "provides new insights for the design of antiretroviral drugs," says the study, referring to the lifeline medication against the human immunodeficiency virus (HIV).

    It is believed to be the first time that gamers have resolved a long-standing scientific problem.

    "We wanted to see if human intuition could succeed where automated methods had failed," Firas Khatib of the university's biochemistry lab said in a press release. "The ingenuity of game players is a formidable force that, if properly directed, can be used to solve a wide range of scientific problems."

    One of Foldit's creators, Seth Cooper, explained why gamers had succeeded where computers had failed.

    "People have spatial reasoning skills, something computers are not yet good at," he said.

    "Games provide a framework for bringing together the strengths of computers and humans. The results in this week's paper show that gaming, science and computation can be combined to make advances that were not possible before."

    Online gamers crack AIDS enzyme puzzle | Games Blog - Yahoo! Games
    can't post pics because my computer's broken and i'm stupid

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    Elite Member Brookie's Avatar
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    Fascinating - but let's see how long it takes to produce real-world results. This could be really great news.
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    Please somebody come up with some kind of game thingy so they can fix our economy!

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    Elite Member McJag's Avatar
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    Quote Originally Posted by darksithbunny View Post
    Please somebody come up with some kind of game thingy so they can fix our economy!
    They could, but no politician would stop talking long enough to notice.
    Then they would demand to know the gamers political leanings.
    I didn't start out to collect diamonds, but somehow they just kept piling up.-Mae West

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