The stunning actress locked lips with the handsome British star in the film and revealed it was an unforgettable experience.
When asked who she would choose to smooch in a movie, the former 'Friends' beauty said: "Let it be Clive Owen. He's just dashing. He's debonair and dreamy."
Aniston also admitted she had a slight crush on co-star Vincent Cassel - despite the fact they shot a harrowing rape scene together for the film.
The actress added to Britain's GQ magazine: "If you're going to be raped in a movie, it may as well be Vincent Cassel. I guess I was doing pretty good on both ends."