My mom had a mole removed from her foot because the doc said it could grow cancerous.
My SIL had a mole removed from her face. It was umm sort of large protruding one that sat on her nose, this was purely cosmetic but she faked that it was hurting to convince her doc to remove it.
Neither of them had any problems since the removal.
I think Enrique Eglesias had his mole removed, too...